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Product Name
MTO1 antibody
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Description
MTO1 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue, Jurkat cells. Observed molecular weight by Western-blot: 70-75kd
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Tested applications
ELISA, WB
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
MTO1 antibody; CGI 02 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MTO1 recombinant protein (Accession Number: BC005808). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:112791(MTO1 antibody) at dilution of 1:500
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Background
MTO1 represents mitochondrial translation optimization 1 homolog (S. cerevisiae)
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References
- Ghezzi D, Baruffini E, Haack TB. Mutations of the mitochondrial-tRNA modifier MTO1 cause hypertrophic cardiomyopathy and lactic acidosis. American journal of human genetics. 90(6):1079-87. 2012.
- Boczonadi V, Smith PM, Pyle A. Altered 2-thiouridylation impairs mitochondrial translation in reversible infantile respiratory chain deficiency. Human molecular genetics. 22(22):4602-15. 2013.
- Meseguer S, Martínez-Zamora A, García-Arumí E, Andreu AL, Armengod ME. The ROS-sensitive microRNA-9/9* controls the expression of mitochondrial tRNA-modifying enzymes and is involved in the molecular mechanism of MELAS syndrome. Human molecular genetics. 24(1):167-84. 2015.
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