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  • MTM1 antibody
  • MTM1 antibody
  • MTM1 antibody

MTM1 antibody

Cat.#: 112781

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Special Price 239.0 USD

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Product Information

  • Product Name
    MTM1 antibody
  • Documents
  • Description
    MTM1 Rabbit Polyclonal antibody. Positive IHC detected in human osteosarcoma tissue. Positive WB detected in L02 cells, Jurkat cells. Observed molecular weight by Western-blot: 63kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    CG2 antibody; CNM antibody; MTM1 antibody; MTMX antibody; Myotubularin antibody; myotubularin 1 antibody; XLMTM antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of MTM1 recombinant protein (Accession Number: BC030779). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    L02 cells were subjected to SDS PAGE followed by western blot with Catalog No:112781(MTM1 antibody) at dilution of 1:1000

    L02 cells were subjected to SDS PAGE followed by western blot with Catalog No:112781(MTM1 antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human osteosarcoma using Catalog No:112781(MTM1 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human osteosarcoma using Catalog No:112781(MTM1 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human osteosarcoma using Catalog No:112781(MTM1 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human osteosarcoma using Catalog No:112781(MTM1 antibody) at dilution of 1:100 (under 40x lens)

  • Background
    The MTM1(Myotubularin) gene encodes a protein that belongs to a family of putative tyrosine phosphatases. It is required for muscle cell differentiation. The protein is also a potent phosphatidylinositol 3-phosphate (PI3P) phosphatase, which is a 66 kDa ubiquitous protein that is found mutated in the X-linked genetic disorder myotubular myopathy(XLMTM).MTM1 could therefore act as a regulator of the highly active phosphoinositide (PI) metabolism in cells, where interconversions of the eight PIs described so far is controlled by a set of specific kinases and phosphatases(PMID:14660569).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"