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Product Name
MTM1 antibody
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Description
MTM1 Rabbit Polyclonal antibody. Positive IHC detected in human osteosarcoma tissue. Positive WB detected in L02 cells, Jurkat cells. Observed molecular weight by Western-blot: 63kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CG2 antibody; CNM antibody; MTM1 antibody; MTMX antibody; Myotubularin antibody; myotubularin 1 antibody; XLMTM antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MTM1 recombinant protein (Accession Number: NM_001376908). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
L02 cells were subjected to SDS PAGE followed by western blot with Catalog No:112781(MTM1 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human osteosarcoma using Catalog No:112781(MTM1 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human osteosarcoma using Catalog No:112781(MTM1 antibody) at dilution of 1:100 (under 40x lens)
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Background
The MTM1(Myotubularin) gene encodes a protein that belongs to a family of putative tyrosine phosphatases. It is required for muscle cell differentiation. The protein is also a potent phosphatidylinositol 3-phosphate (PI3P) phosphatase, which is a 66 kDa ubiquitous protein that is found mutated in the X-linked genetic disorder myotubular myopathy(XLMTM).MTM1 could therefore act as a regulator of the highly active phosphoinositide (PI) metabolism in cells, where interconversions of the eight PIs described so far is controlled by a set of specific kinases and phosphatases(PMID:14660569).
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