MTH1 Rabbit Polyclonal antibody. Positive IHC detected in human lung cancer tissue. Positive IF detected in PC-3 cells. Positive WB detected in HepG2 cells, HEK-293 cells, PC-3 cells. Observed molecular weight by Western-blot: 18-24 kDa
ELISA, IHC, WB, IF
Human,Mouse,Rat; other species not tested.
MTH 1 antibody; MTH1 antibody; NUDT1 antibody
This antibody was obtained by immunization of MTH1 recombinant protein (Accession Number: NM_198954). Purification method: Antigen affinity purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:112775(NUDT1 antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:112775(NUDT1 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:112775(NUDT1 antibody) at dilution of 1:50 (under 40x lens)
Immunofluorescent analysis of PC-3 cells using Catalog No:112775(NUDT1 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
MTH1, also known as NUDT1 or 8-Oxo-dGTPase, is an important repair enzyme that prevents oxidative stress-induced DNA damage through hydrolyzing mutagenic 8-oxo-dGTP into 8-oxo-dGMP. MTH1 is expressed in postmitotic neurons as well as in proliferative tissues, and it is localized both in the mitochondria and nucleus. MTH1 might be a useful marker of oxidative stress and its level increased upon oxidative stress. Increased expression of MTH1 were also found in various cancer tissues and neurodegenerative diseases.
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