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Product Name
Mouse S100a11/S100c (His tag) recombinant protein
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Description
Protein S100-A11(S100A11) is a member of the S-100 family. S100A11 is widely expressed in multi pletissues, and is located in cytoplasm, nucleus, and even cell periphery. S100A11 exists as a non-covalent homodimer with an antiparallel conformation. Ca(2+) binding to S100A11 would trigger conformational changes which would expose the hydrophobic cleft of S100A11 and facilitate its interaction with target proteins. As a dual cell growth mediator, S100A11 acts as either a tumor suppressor or promoter in many different types of tumors and would play respective roles in influencing the proliferatin of the cancer cells. In the nucleus, S100A11 suppresses the growth of keratinocytes through p21 (CIP1/WAF1) activation and induces cell differentiation. S100A11 is also a novel diagnostic marker in breast carcinoma.
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Protein name
S100 calcium binding protein A11(S100a11)
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Protein short names
S100c
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Uniprot ID
P50543
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Mouse S100a11/S100c Met1-Ile98 is expressed with a 6His at the N-terminus.
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Protein Species
Mouse
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Purity
>95% as determined by SDS-PAGE.
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Validations
Mouse S100a11/S100c (His tag) recombinant protein
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