-
Product Name
Mouse IL13RA1/IL-13RA1 (His Tag) recombinant protein
- Documents
-
Description
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. IL13RA1/IL-13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13RA1/IL-13RA1 binds with low affinity to interleukin-13 (IL13). This subunit together with IL4RA can form a functional receptor for IL13. IL13RA1/IL-13RA1 also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
-
Protein name
Interleukin-13 receptor subunit alpha-1
-
Protein short names
IL-13RA; IL-13R[A]; RP13-128O4.2; RP23-132G2.1; IL13RA; NR4; IL13RA1; CD213A1; AI882074
-
Uniprot ID
Q8BNM4
-
Gene Name
Il13ra1; Il13r; Il13ra
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Thr 340) of mouse IL13R?1 (NP_598751.3) precursor was fused with the a polyhistidine tag at the C-terminus.
-
Protein Species
Mouse
-
Molecular weight
The recombinant mouse IL13R?1 consists of 326 amino acids after removal of the signal peptide and has a predicted molecular mass of 37.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm IL13R?1 is approximately 50-55 kDa due to glycosylation.
-
Purity
> 98 % as determined by SDS-PAGE
-
Validations
Mouse IL13RA1 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"