Anti-IL13RA1/IL-13RA1 antibody

Anti-IL13RA1/IL-13RA1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to IL13RA1/IL-13RA1

FCM

Human IL13RA1 / IL-13RA1

AI882074 antibody; CD213A1 antibody; CD213a1 antibody; IL-13r[a] antibody; Il13ra antibody; IL-13Ra antibody; IL13RA1 antibody; Il13ra1 antibody; NR4 antibody; NR4 antibody; RP13-128O4.2 antibody; RP23-132G2.1 antibody; NR4 antibody; CD213A1 antibody; IL-13Ra antibody; NR4 antibody; Il13ra antibody; CD213a1 antibody; AI882074 antibody; IL-13r[a] antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human IL13RA1 / IL-13RA1 (rh IL13RA1 / IL-13RA1; NP_001551.1; Met1-Thr343) and conjugated with APC under optimum conditions, the unreacted APC was removed.

Monoclonal

Aqueous solution containing 0.5% BSA and 0.09% sodium azide

This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

FCM

Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. IL13RA1/IL-13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13RA1/IL-13RA1 binds with low affinity to interleukin-13 (IL13). This subunit together with IL4RA can form a functional receptor for IL13. IL13RA1/IL-13RA1 also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

• Kawakami M, et al. (2002) Mutation and functional analysis of IL-13 receptors in human malignant glioma cells. Oncol Res. 12 (11-12): 459-67.
• Umeshita-Suyama R, et al. (2000) Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation. Int Immunol. 12 (11): 1499-509.
• He JQ, et al. (2003) Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers. Am J Respir. Cell Mol Biol. 28 (3): 379-85.