Mouse Ephrin-A2/EFNA2 recombinant protein

Mouse Ephrin-A2/EFNA2 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Ephrin-A2 also known as EFNA2 or EPH-related receptor tyrosine kinase ligand 6, is a member of the ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A2 and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A2 regulates the position-specific affinity of limb mesenchyme and is involved in cartilage pattern formation in the limb.

Ephrin-A2

LERK6; EPHRIN-A2; LERK-6; CEK7L; ELF1; EPL6; ELF-1; EFNA2; EPLG6; HEK7-L

Q3USB4

Efna2; Elf1; Epl6; Eplg6; Lerk6

Human Cells

A DNA sequence encoding the mouse EFNA2 (NP_031935.3) without the pro peptide (Met 1-Asn 184) was expressed and purified, with additional seven amino acid (ALEVLFQ) at the C-terminus.

Mouse

The recombinant mouse EFNA2 consists of 169 amino acids and has a predicted molecular mass of 19.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmEFNA2 is approximately 28 kDa due to glycosylation.

> 97 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA.
2. Immobilized recombinant Coating: Mouse EFNA2 (native) (cat: 504259) at 10μg/ml (100 μl/well) can bind Mouse EphA4-Fc (cat: 501692) with a linear range of 1.25-10 μg/mL.