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Product Name
Mouse Ephrin-A2/EFNA2 (His Tag) recombinant protein
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Description
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
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Protein name
Ephrin-A2
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Protein short names
EFNA2; ELF-1; EPLG6; HEK7-L; LERK6; EPHRIN-A2; CEK7L; LERK-6; EPL6; ELF1
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Uniprot ID
Q3USB4
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Gene Name
Efna2; Elf1; Epl6; Eplg6; Lerk6
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse EFNA2 (NP_031935.3) without the pro peptide (Met 1-Asn 184) was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse EFNA2 consists of 173 amino acids and has a predicted molecular mass of 20 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmEFNA2 is approximately 35-40 kDa due to glycosylation.
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Purity
> 94 % as determined by SDS-PAGE
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Activity
1. Measured by its binding ability in a functional ELISA.
2. Immobilized mouse EFNA2-his at 10 μg/mL (100 μl/well) can bind mouse EphA4-Fc (Cat: 501692). The EC50 of mouse EphA4-Fc is 0.57 μg/mL. -
Validations
Mouse Ephrin-A2 / EFNA2 Protein (His Tag) SDS-PAGE
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