Mouse EphB4/Eph Receptor B4 (Fc Tag) recombinant protein

Mouse EphB4/Eph Receptor B4 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity. Furthermore, EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. EphB4 protein has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Therefore, Ephrin-B2/EphB4 may be recognized as a novel prognostic indicator for cancers.

Ephrin type-B receptor 4

MYK1; EPHB4; HTK; AI042935; MDK2; TYRO11

P54761

Ephb4; Htk; Mdk2; Myk1

Human Cells

A DNA sequence encoding the mouse EPHB4 (P54761-1) extracellular domain (Met 1-Ala 539) was fused with the Fc region of human IgG1 at the C-terminus.

Mouse

The secreted recombinant mouse EPHB4/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 765 amino acids and has a predicted molecular mass of 84.7 kDa. As a result of glycosylation, the apparent molecular mass of rm EPHB4/Fc monomer is approximately 110 kDa in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA.
2. Immobilized mouse EPHB2-His (Cat:500099) at 10 μg/mL (100 μl/well) can bind mouse EPHB4-Fc (Cat:503845), The EC₅₀ of mouse EPHB4-Fc (Cat:503845) is 15 ng/mL.