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Product Name
Mouse EphA6 / EHK2 / Eph Receptor A6 (His Tag) recombinant protein
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Description
Ephrin type-A receptor 6, also known as EphA6 or EHK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor−mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. In the vomeronasal system, Ephrin-A5/EphA6 interactions mediate attraction or adhesion rather than repulsion.
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Protein name
Receptor protein-tyrosine kinase
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Protein short names
M-EHK2; FLJ35246; DKFZP434C1418; HEK12; EPHA6; EHK-2; EK12; EPA6; UNQ6114; PRO57066; EHK2
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Uniprot ID
G1K381
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Gene Name
Epha6
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse EphA6 (NP_031964.2) (Met 1-Gln 546) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse EphA6 comprises 530 amino acids and has a calculated molecular mass of 59.5 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse EphA6 at 2 μg/ml (100 μl/well) can bind recombinant human EphrinA3 at a linear range of 0.31-10 ng/ml.
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Validations
Mouse EphA6 / EHK-2 Protein (His Tag) SDS-PAGE
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