Mouse DKK1 recombinant protein (C-His)

Mouse DKK1 recombinant protein (C-His)

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• Material Safety Data Sheets (MSDS)

Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

Dickkopf-related protein 1

mdkk-1

O54908

Dickkopf-related protein 1; Dickkopf-1; Dkk-1; mDkk-1

Human Cells

A DNA sequence encoding the mouse DKK1 (NP_034181.2) (Met1-His272) was expressed with a polyhistidine tag at the C-terminus.

Mouse

The recombinant mouse DKK1 consists of 252 amino acids and predicts a molecular mass of 27.6 kDa.

> 95 % as determined by SDS-PAGE.

Measured by its ability to inhibit recombinant rmWnt3a induced alkaline phosphatase production by C3H10T 1/2 cells. The ED₅₀ for this effect is 0.05-0.3 μg/mL.