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Mouse DDR1/MCK10/CD167 (His & GST Tag) recombinant protein

Cat.#: 504274

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Product Information

  • Product Name
    Mouse DDR1/MCK10/CD167 (His & GST Tag) recombinant protein
  • Documents
  • Description
    Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.
  • Protein name
    Epithelial discoidin domain-containing receptor 1
  • Protein short names
    NEP; CD167A; CAK; AI323681; HGK2; DAAP-278B20.1; EDDR1; TRKE; NTRK4; DDR; MCK10; PTK3; 6030432F18; DDR1; PTK3A; RTK6; CD167
  • Uniprot ID
    Q03146
  • Gene Name
    Ddr1; Cak; Eddr1; Mpk6
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse DDR1 (Q03146-2) (Leu444-Val874) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse DDR1/GST chimera consists of 668 amino acids and has a calculated molecular mass of 75.8kDa. The recombinant protein migrates as an approximately 68 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    The specific activity was determined to be 2 nmol/min/mg using synthetic modified AXLtide peptide (modified-CKKSRGDYMTMQIG) as substrate.
  • Validations

    Mouse DDR1 Kinase / MCK10 / CD167 Protein (His & GST Tag) SDS-PAGE

    Mouse DDR1 Kinase / MCK10 / CD167 Protein (His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"