Rat DDR1/MCK10/CD167 (Fc Tag) recombinant protein

Rat DDR1/MCK10/CD167 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.

Discoidin domain receptor family, member 1

PTK3A; CD167; RTK6; MCK10; DDR1; 6030432F18; PTK3; EDDR1; HGK2; AI323681; DAAP-278B20.1; CAK; DDR; NTRK4; TRKE; CD167A; NEP

Q6MG19

Ddr1; Cdk2ap1-ps7; Cdk2ap1-ps8; E030032D13Rik; LOC224733l-9; Rpl22-ps; RT1-CE14; RT1-CE16; Tcf19; rCG_41823

Human Cells

A DNA sequence encoding the rat DDR1 (Q6MG19) (Met1-Thr413) was expressed with the Fc region of human IgG1 at the C-terminus.

Rat

The recombinant rat DDR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 635 amino acids and has a predicted molecular mass of 70.9 kDa. The apparent molecular mass of the protein is approximately 71 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE