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Product Name
Mouse DDR1/MCK10/CD167 (His Tag) recombinant protein
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Description
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.
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Protein name
Epithelial discoidin domain-containing receptor 1
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Protein short names
MCK10; DDR1; PTK3; 6030432F18; PTK3A; RTK6; CD167; NEP; CD167A; CAK; DAAP-278B20.1; HGK2; AI323681; EDDR1; DDR; TRKE; NTRK4
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Uniprot ID
Q544T2
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Gene Name
Ddr1; Cak; Eddr1; Mpk6
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse DDR1 (NP_766550.1) (Met 1-Thr 414) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse DDR1 comprises 406 amino acids and has a calculated molecular mass of 45.4 kDa. As a result of glycosylation, the apparent molecular mass of rm DDR1 is approximately 50 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Mouse DDR1 Kinase / MCK10 / CD167 Protein (His Tag) SDS-PAGE
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