Mouse CDCP1 (Fc Tag) recombinant protein

Mouse CDCP1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and in both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.

CUB domain-containing protein 1

SUBTRACTIVE IMMUNIZATION M PLUS HEP3-ASSOCIATED 135 KDA PROTEIN; AA409659; SIMA135; 9030022E12RIK; E030027H19RIK; TRASK; MEMBRANE GLYCOPROTEIN GP140; TRANSMEMBRANE AND ASSOCIATED WITH SRC KINASES; CD318; UNQ2486/PRO5773; CUB DOMAIN-CONTAINING PROTEIN 1

Q5U462

Cdcp1

Human Cells

A DNA sequence encoding the mouse CDCP1 (Q5U462) (Met1-Leu666) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Mouse

The recombinant mouse CDCP1 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 878 amino acids and has a predicted molecular mass of 98.8 kDa. The apparent molecular mass of the protein is approximately 117 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 79 % as determined by SDS-PAGE