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Product Name
Human CDCP1/TRASK/UNQ2486/PRO5773 (His tag) recombinant protein
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Description
CUB domain-containing protein 1(CDCP1) is a transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD) containing five tyrosines. CDCP1 is widely expressed in human epithelial tissues, but its phosphorylation is only seen in mitotically detached or shedding cells, consistent with its role in the negative regulation of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsinor EDTA, or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype.
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Protein name
CUB domain containing protein 1(CDCP1)
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Protein short names
TRASK; UNQ2486; PRO5773
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Uniprot ID
Q9H5V8
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human CDCP1/TRASK/UNQ2486/PRO5773 Phe30-Ser341 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human CDCP1/TRASK/UNQ2486/PRO5773 (His tag) recombinant protein
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