Mouse Cadm1/Igsf4/Necl2/Ra175 (Fc tag) recombinant protein

Cat.#: 519646

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Product Information

  • Product Name
    Mouse Cadm1/Igsf4/Necl2/Ra175 (Fc tag) recombinant protein
  • Documents
  • Description
    Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. CADM1 may contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, it may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. The protein acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. It may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
  • Protein name
    cell adhesion molecule 1(Cadm1)
  • Protein short names
    Igsf4; Necl2; Ra175; Syncam; SynCam1; Tslc1
  • Uniprot ID
    Q8R5M8
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Mouse Cadm1/Igsf4/Necl2/Ra175 Gln48-His388 is expressed with a Fc tag at the C-terminus.
  • Protein Species
    Mouse
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Mouse Cadm1/Igsf4/Necl2/Ra175 (Fc tag) recombinant protein

    Mouse Cadm1/Igsf4/Necl2/Ra175 (Fc tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"