Human SynCam/CADM1/TSLC1/IGSF4 (His Tag) recombinant protein
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Cell adhesion molecule 1
Protein short names
MGC149785; 2900073G06RIK; NECL-2; SGIGSF; IGSF4; IGSF4A; SYNCAM1; RA175N; AI987920; CADM1; SYNCAM; RA175B; MGC51880; ST17; STSLC-1; DKFZP686F1789; NECL2; RA175C; TSLC1; RA175A; RA175; BL2; 3100001I08RIK
CADM1; IGSF4; IGSF4A; NECL2; SYNCAM; TSLC1
A DNA sequence encoding the human CADM1 (NP_055148.3) extracellular domain (Met 1-His 374) was expressed, fused with a polyhistidine tag at the C-terminus.
The secreted recombinant human CADM1 consists of 341 amino acids after removal of the signal peptide and has a predicted molecular mass of 38.5 kDa. As a result of glycosylation, the apparent molecular masss of rh CADM1 is approximately 70-80 kDa in SDS-PAGE under reducing conditions.
> 94 % as determined by SDS-PAGE
Measured by its binding ability in a functional ELISA. Immobilized recombinant human CADM1 at 2 μg/ml (100 μl/well) can bind biotinylated human CRTAM with a linear range of 12.5-400 ng/ml.
Human SynCam / CADM1 / TSLC1 / IGSF4 Protein (His Tag) SDS-PAGE
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