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Product Name
CADM1 antibody
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Description
CADM1 Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue, A549 cells, human placenta tissue, mouse lung tissue. Observed molecular weight by Western-blot: 49-60 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
BL2 antibody; CADM1 antibody; cell adhesion molecule 1 antibody; DKFZp686F1789 antibody; IGSF4 antibody; IGSF4A antibody; Necl 2 antibody; NECL2 antibody; Nectin like protein 2 antibody; RA175 antibody; sgIGSF antibody; ST17 antibody; sTSLC 1 antibody; SYNCAM antibody; synCAM1 antibody; TSLC 1 antibody; TSLC1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CADM1 recombinant protein (Accession Number: BC047021). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:108811(CADM1 antibody) at dilution of 1:1000
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Background
CADM1 (cell adhesion molecule 1), also referred to as SgIGSF, Necl-2 or TSLC-1, is a cell adhesion molecule belonging to the immunoglobulin superfamily. It can mediate homophilic and heterophilic cell-cell adhesion. CADM1 is expressed by a variety of cells including neurons, mast cells, spermatogonia, pancreatic islet cells, epithelial cells such as lung alveolar cells and biliary epithelial cells. CADM1 is involved in carcinoma pathogenesis and the expression of CADM1 is frequently down-regulated in various tumors derived from epithelial cells. It acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. (PMID: 18332875; 17326163; 20340131)
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References
- Zhu Y, Li H, Li K. Necl-4/SynCAM-4 is expressed in myelinating oligodendrocytes but not required for axonal myelination. PloS one. 8(5):e64264. 2013.
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