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Product Name
Mouse AGRP (His Tag) recombinant protein
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Description
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.
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Protein name
Agouti-related protein
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Protein short names
ART; MGC118963; ASIP2; AGRP; AGRT
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Uniprot ID
P56473
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Gene Name
Agrp; Agrt; Art
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse AGRP (P56473) (Met 1-Thr 131) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse AGRP comprises 122 amino acids and has a calculated molecular mass of 13.7 kDa. The recombinant protein migrates as an approximately 20 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 80 % as determined by SDS-PAGE
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Validations
Mouse AGRP / AgRP Protein (His Tag) SDS-PAGE
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