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Product Name
Human AGRP (Fc Tag) recombinant protein
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Description
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.
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Protein name
Agouti related protein homolog (Mouse)
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Protein short names
AGRT; MGC118963; ASIP2; AGRP; ART
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Uniprot ID
O00253
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Gene Name
AgRP; AGRP; hCG_28814
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human AgRP (NP_001129.1) (Met 1-Thr 132) was expressed with the fused Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human AgRP/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 350 amino acids and predicts a molecular mass of 39 kDa also estimated by SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human AgRP Protein (Fc Tag) SDS-PAGE
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