MKS3 antibody

Cat.#: 112671

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Product Information

  • Product Name
    MKS3 antibody
  • Documents
  • Description
    MKS3 Rabbit Polyclonal antibody. Positive IF detected in hTERT-RPE1 cells. Positive IHC detected in human kidney tissue, human hepat℃irrhosis tissue.
  • Tested applications
    ELISA, IF, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    JBTS6 antibody; Meckel syndrome type 3 protein antibody; MECKELIN antibody; MKS3 antibody; TMEM67 antibody; TNEM67 antibody; transmembrane protein 67 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of MKS3 recombinant protein (Accession Number: BC032835). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    IHC: 1:20-1:200

    IF: 1:20-1:200

  • Validations

    IF result from Dr. Corbit, Kevin. anti-MKS3(Catalog No:112671) marks the proximal transition zone and basal body of Human hTERT-RPE1 cells and Mouse embryonic fibroblasts.

    IF result from Dr. Corbit, Kevin. anti-MKS3(Catalog No:112671) marks the proximal transition zone and basal body of Human hTERT-RPE1 cells and Mouse embryonic fibroblasts.

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:112671(TMEM67 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:112671(TMEM67 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:112671(TMEM67 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:112671(TMEM67 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    TMEM67 represents transmembrane protein 67
  • References
    • Garcia-Gonzalo FR, Corbit KC, Sirerol-Piquer MS. A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition. Nature genetics. 43(8):776-84. 2011.
    • Goetz SC, Liem KF, Anderson KV. The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell. 151(4):847-58. 2012.
    • Wang WJ, Tay HG, Soni R. CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base. Nature cell biology. 15(6):591-601. 2013.
    • Yang Y, Ran J, Liu M. CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell research. 24(11):1342-53. 2014.
    • Barbelanne M, Hossain D, Chan DP, Peränen J, Tsang WY. Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery. Human molecular genetics. 24(8):2185-200. 2015.
    • Roberson EC, Dowdle WE, Ozanturk A. TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone. The Journal of cell biology. 209(1):129-42. 2015.
    • Ran J, Yang Y, Li D, Liu M, Zhou J. Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly. Scientific reports. 5:12917. 2015.
    • Lu Q, Insinna C, Ott C. Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation. Nature cell biology. 17(4):531. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"