Human LC3B / MAP1LC3B (His Tag) recombinant protein

Human LC3B / MAP1LC3B (His Tag) recombinant protein

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Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Microtubule-associated proteins 1A/1B light chain 3B

MAP1LC3B-A; LC3B; MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3B; MAP1 LIGHT CHAIN 3-LIKE PROTEIN 2; MAP1A/1BLC3; MAP1A/MAP1B LC3 B; MAP1LC3; ATG8; AUTOPHAGY-RELATED UBIQUITIN-LIKE MODIFIER LC3 B; MICROTUBULE-ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 BETA; AUTOPHAGY-RELATED PROTEIN LC3 B; MAP1A/MAP1B LIGHT CHAIN 3 B; ATG8F; 1010001C15RIK; MAP1LC3B

Q9GZQ8

MAP1LC3B; MAP1ALC3

E. coli

A DNA sequence encoding the human MAP1LC3B (Q9GZQ8) (Met1-Val125) was expressed with a polyhistidine tag at the N-terminus.

Human

The recombinant human MAP1LC3B consists of 140 amino acids and predicts a molecular mass of 16.5 KDa. It migrates as an approximately 17 KDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE