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Product Name
Human MAP2 (His Tag) recombinant protein
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Description
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
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Protein name
Methionine aminopeptidase 2
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Protein short names
METAP 2; 4930584B20RIK; AI047573; EIF-2-ASSOCIATED P67; AU014659; MNPEP; AMP2; INITIATION FACTOR 2-ASSOCIATED 67 KDA GLYCOPROTEIN; MAP2; P67; EIF-2-ASSOCIATED P67 HOMOLOG; A930035J23RIK; PEPTIDASE M 2; P67EIF2; INITIATION FACTOR 2-ASSOCIATED PROTEIN (P67); MAP 2; AL024412; METHIONINE AMINOPEPTIDASE 2
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Uniprot ID
P50579
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Gene Name
METAP2; MNPEP; P67EIF2
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human METAP2 (NP_006829.1) (Met1-Tyr478) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human METAP2 consists 489 amino acids and predicts a molecular mass of 54.3 kDa.
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Purity
> 85 % as determined by SDS-PAGE.
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Validations
Human METAP2 / MAP2 Protein (His Tag)
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