Anti-METAP2 antibody

Cat.#: 141830

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Product Information

  • Product Name
    Anti-METAP2 antibody
  • Documents
  • Description
    Rabbit Polyclonal to Human METAP2
  • Tested applications
  • Species reactivity
    Human MAP2
  • Alternative names
    p67 antibody; MAP2 antibody; MNPEP antibody; p67eIF2 antibody; p67 antibody; Amp2 antibody; Mnpep antibody; p67eIF2 antibody; AI047573 antibody; AL024412 antibody; AU014659 antibody; 4930584B20Rik antibody; A930035J23Rik antibody; P67 antibody; Amp2 antibody; eIF-2-associated p67 antibody; eIF-2-associated p67 homolog antibody; initiation factor 2-associated 67 kDa glycoprotein antibody; initiation factor 2-associated 67 kDa glycoprotein antibody; initiation factor 2-associated protein (p67) antibody; MAP 2 antibody; MAP 2 antibody; MAP2 antibody; metAP 2 antibody; metAP 2 antibody; methionine aminopeptidase 2 antibody; Mnpep antibody; MNPEP antibody; p67 antibody; p67eIF2 antibody; p67eIF2 antibody; peptidase M 2 antibody; peptidase M 2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human MAP2, and purified by antigen affinity chromatography.
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 0.1-2μg/mL

  • Validations

    Human MAP2 Immunohistochemistry(IHC) 15457

    Human MAP2 Immunohistochemistry(IHC) 15457

    Human MAP2 Immunohistochemistry(IHC) 15458

    Human MAP2 Immunohistochemistry(IHC) 15458

  • Background
    METAP2 (Methionine aminopeptidase 2), also known as MAP2 is a a protein which belongs to the peptidase M24A family. MAP2 binds 2 cobalt or manganese ions and contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. It is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation. The catalytic activity of human MAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. MAP2 protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. It also plays a critical role in the regulation of protein synthesis.