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MEIS2 antibody

Cat.#: 112640

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Product Information

  • Product Name
    MEIS2 antibody
  • Documents
  • Description
    MEIS2 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, PC-3 cells. Positive IHC detected in human prostate cancer tissue. Observed molecular weight by Western-blot: 56kd
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Homeobox protein Meis2 antibody; HsT18361 antibody; Meis homeobox 2 antibody; Meis1 related protein 1 antibody; MEIS2 antibody; MRG1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of MEIS2 recombinant protein (Accession Number: NM_002399). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:112640(MEIS2 antibody) at dilution of 1:500

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:112640(MEIS2 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:112640(MEIS2 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:112640(MEIS2 antibody) at dilution of 1:50 (under 10x lens)

  • Background
    MEIS2, also named as Meis1-related protein 1 or MRG1, is a 477 amino acid protein, which contains one homeobox DNA-binding domain and belongs to the TALE/MEIS homeobox family. MEIS2 is expressed in various tissues and at high level in the lymphoid organs of hematopoietic tissues. MEIS2 localizes in the nucleus and is involved in transcriptional regulation. MEIS2 is a critical downstream effector within an essential homeoprotein network that serving a rate-limiting regulatory role in MLL leukemogenesis. MEIS2 as midbrain specific marker is upregulated concomitantly with the morphological transformation of hindbrain to midbrain.
  • References
    • Russell MK, Longoni M, Wells J. Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes. Proceedings of the National Academy of Sciences of the United States of America. 109(8):2978-83. 2012.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"