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Maspin antibody

Cat.#: 112488

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Product Information

  • Product Name
    Maspin antibody
  • Documents
  • Description
    Maspin Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, A431 cells, HeLa cells. Positive IHC detected in human lung cancer tissue, human breast cancer tissue. Observed molecular weight by Western-blot: 42 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    maspin antibody; Peptidase inhibitor 5 antibody; PI 5 antibody; PI5 antibody; Serpin B5 antibody; SERPINB5 antibody; SPB5 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Maspin recombinant protein (Accession Number: BC020713). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:50-1:500

  • Validations

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:112488(SERPINB5 antibody) at dilution of 1:500

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:112488(SERPINB5 antibody) at dilution of 1:500

    Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using Catalog No:112488(SERPINB5 Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using Catalog No:112488(SERPINB5 Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using Catalog No:112488(SERPINB5 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using Catalog No:112488(SERPINB5 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

  • Background
    SERPINB5, also named as PI-5, Maspin and Serpin B5, belongs to the serpin family and Ov-serpin subfamily. It is a tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, SERPINB5 exhibits no serine protease inhibitory activity.
  • References
    • Baek JY, Yeo HY, Chang HJ. Serpin B5 is a CEA-interacting biomarker for colorectal cancer. International journal of cancer. 134(7):1595-604. 2014.
    • Yang CF, Peng LX, Huang TJ. Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway. Cancer letters. 344(2):260-71. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"