MARCKSL1 antibody

MARCKSL1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MARCKSL1 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue. Positive IHC detected in human lung cancer tissue, human liver cancer tissue, human pancreas cancer tissue. Observed molecular weight by Western-blot: 48 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

F52 antibody; Mac MARCKS antibody; MACMARCKS antibody; MARCKS like 1 antibody; MARCKS like protein 1 antibody; MARCKS related protein antibody; MARCKSL1 antibody; MLP antibody; MLP1 antibody; MRP antibody

Rabbit IgG

This antibody was obtained by immunization of MARCKSL1 recombinant protein (Accession Number: NM_023009). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

MARCKS-like protein 1 (MARCKSL1) is widely expressed in nervous tissue, it is also named MARCKS-like protein (MLP) or MARCKS-related protein (MRP) and belongs to the MARCKS family, which is a highly acidic myristoylated family of PKC substrates widely distributed in diverse cell types including macrophages. The protein has a calculated molecular weight of 20 kDa and an apparent molecular weight of 42-48 kDa due to anomalous migration on SDS gels or phosphorylation. Genetic disruption of MARCKSL1 results in neural tube closure defects, events that depend on coordinated control of actin functions, cell shape, and cell migration. MARCKSL1 are thought to regulate the actin cytoskeleton and thereby participate in major cellular responses such as phagocytosis, secretion, motility, mitogenesis, and membrane trafficking.

• Turtoi A, Musmeci D, Naccarato AG. Sparc-like protein 1 is a new marker of human glioma progression. Journal of proteome research. 11(10):5011-21. 2012.