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Product Name
MAOA antibody
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Description
MAOA Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue, human kidney tissue, human liver tissue, human pancreas tissue. Positive IP detected in human placenta tissue. Positive WB detected in human placenta tissue. Observed molecular weight by Western-blot: 60 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human; other species not tested.
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Alternative names
MAO A antibody; MAOA antibody; monoamine oxidase A antibody; Monoamine oxidase type A antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MAOA recombinant protein (Accession Number: NM_000240). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:112469(MAOA antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:112469(MAOA antibody) at dilution of 1:100 (under 25x lens)
IP Result of anti-MAOA (IP:Catalog No:112469, 3ug; Detection:Catalog No:112469 1:600) with human placenta tissue lysate 2800ug.
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Background
MAOA belongs to the flavin monoamine oxidase family. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
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References
- Saller S, Merz-Lange J, Raffael S. Norepinephrine, active norepinephrine transporter, and norepinephrine-metabolism are involved in the generation of reactive oxygen species in human ovarian granulosa cells. Endocrinology. 153(3):1472-83. 2012.
- Lee NC, Shieh YD, Chien YH. Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency. Neurobiology of disease. 52:177-90. 2013.
- Sai T, Uchida K, Nakayama H. Changes of MAO-A and MAO-B Expressions in the Placenta of MPTP or MPP(+) Treated Mice. Journal of toxicologic pathology. 26(1):73-7. 2013.
- Baandrup JD, Markvardsen LH, Peters CD. Pressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats. PloS one. 6(1):e15859. 2011.
- Li J, Yang XM, Wang YH. Monoamine oxidase A suppresses hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling. Journal of hepatology. 60(6):1225-34. 2014.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"