Human LOXL2 (His Tag) recombinant protein

Human LOXL2 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein which belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent propeptide regions. LOX family enzyme activities catalyze the final enzymatic conversion required for the formation of normal biosynthetic collagen and elastin cross-links. LOXL2 is expressed by pre-hypertrophic and hypertrophic chondrocytes in vivo, and that LOXL2 expression is regulated in vitro as a function of chondrocyte differentiation. LOXL2 promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation. LOXL2 expression could also be explored as a molecular target in the prevention of breast cancer progression.

Lysyl oxidase homolog 2

LOXL2; WS9-14; MGC102220; 4930526G11RIK; 1110004B06RIK; 9430067E15RIK; LOR2

Q9Y4K0

LOXL2

Human Cells

A DNA sequence encoding the human LOXL2 (Q9Y4K0) (Met 1-Gln 774) was expressed, fused with a polyhistidine tag at the C-terminus.

Human

The recombinant human LOXL2 consists of 760 amino acids and has a predicted molecular mass of 85.5 kDa. The apparent molecular mass of rh LOXL2 is approximately 100 & 60 KDa in SDS-PAGE under reducing conditions, corresponding to the unprocessed and processed form respectively.

> 60 % as determined by SDS-PAGE

Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine.
The specific activity is > 2 pmoles/min/μg.