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Product Name
Human LOXL2 (Avi & His tag) recombinant protein
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Description
Lysyl oxidase homolog 2 is a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. LOXL2 can also crosslink collagen type IV and hence influence the sprouting of new blood vessels. LOXL2 is an enzyme that is up-regulated in several types of cancer and is associated with a poorer prognosis. LOXL2 changes the structure of histones and thus changes the shape of the cells, making it easier for the cancer cells to metastasize.
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Protein name
lysyl oxidase like 2(LOXL2)
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Uniprot ID
Q9Y4K0
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human LOXL2 Gln26-Gln774 is expressed fused with a Avi-His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human LOXL2 (Avi & His tag) recombinant protein
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