Human LOXL2 (His Tag) recombinant protein

Cat.#: 504149

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Product Information

  • Product Name
    Human LOXL2 (His Tag) recombinant protein
  • Documents
  • Description
    Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein which belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent propeptide regions. LOX family enzyme activities catalyze the final enzymatic conversion required for the formation of normal biosynthetic collagen and elastin cross-links. LOXL2 is expressed by pre-hypertrophic and hypertrophic chondrocytes in vivo, and that LOXL2 expression is regulated in vitro as a function of chondrocyte differentiation. LOXL2 promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation. LOXL2 expression could also be explored as a molecular target in the prevention of breast cancer progression.
  • Protein name
    Lysyl oxidase homolog 2
  • Protein short names
    LOXL2; WS9-14; MGC102220; 4930526G11RIK; 1110004B06RIK; 9430067E15RIK; LOR2
  • Uniprot ID
    Q9Y4K0
  • Gene Name
    LOXL2
  • Source/Expression Host
    CHO Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human LOXL2 (Q9Y4K0) (Met1-Gln774) was expressed, fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human LOXL2 consists of 760 amino acids and has a predicted molecular mass of 85.5 kDa.
  • Purity
    (67+30) % as determined by SDS-PAGE
  • Activity
    Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine.
    The specific activity is >2pmol/min/μg
  • Validations

    Human LOXL2 / Lysyl oxidase homolog 2 Protein (His Tag)

    Human LOXL2 / Lysyl oxidase homolog 2 Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"