• Human LAMP-1/CD107a/LAMP1 (His Tag) recombinant protein

Human LAMP-1/CD107a/LAMP1 (His Tag) recombinant protein

Cat.#: 501215

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Product Information

  • Product Name
    Human LAMP-1/CD107a/LAMP1 (His Tag) recombinant protein
  • Documents
  • Description
    Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein which belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. LAMP-1 is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP-1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer's disease (AD) stages I-IIA/B and stages V-VIC of Braak and Braak, compared with age-matched controls. LAMP-1 occurred in microglia and multinucleated giant cells in one AD case in whom amyloid burden was cleared following betaA-peptide immunization. In addition, LAMP-1 has been suggested to be a cell surface receptor for a specific amelogenin isoform, leucine-rich amelogenin peptide or LRAP. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts.
  • Protein name
    Lysosomal-associated membrane protein 1, isoform CRA_a
  • Protein short names
    LAMPA; LGP120; LAMP1; LAMP-1; AI196048; CD107A
  • Uniprot ID
    P11279
  • Gene Name
    LAMP1; hCG_27880
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human LAMP1 (NP_005552.3) (Met 1-Met 382) was expressed, with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human LAMP1 consists of 365 amino acids and predictes a molecular mass of 39.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhLAMP1 is approximately 60-100 kDa due to high levels of glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to bind biotinylated recombinant human Galectin-3 (Cat:10289-HNAE-E) in a functional ELISA.
  • Validations

    Human LAMP1 / CD107a Protein (His Tag) SDS-PAGE

    Human LAMP1 / CD107a Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"