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Product Name
Human Leptin Receptor/CD295 (His Tag) recombinant protein
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Description
Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).
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Protein name
Leptin receptor
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Protein short names
LEPRD; OBESE-LIKE; OBR; LEPROT; LEPRB; LEP-R; OBL; OB-R; CD295; OB-RGRP; MGC105189; DIABETES; DB; LEPR; RP23-31K16.2; MODB1
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Uniprot ID
P48357
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Gene Name
LEPR; DB; OBR
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Asp 839) of human leptin receptor (NP_002294.2) was expressed, fused with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The recombinant human LEPR consists of 829 amino acids and has a predicted molecular mass of 95 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh LEPR is approximately 130-140 kDa due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized human Leptin at 5 μg/ml (100 μl/well) can bind human Leptin receptor with a linear range of 0.032-4.0 μg/ml.
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Validations
Human Leptin Receptor / LEPR / CD295 Protein (His Tag) SDS-PAGE
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