Anti-LEPR antibody

Anti-LEPR antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Rat LEPR

IHC-P

Rat Leptin Receptor / CD295

OBR antibody; OB-R antibody; CD295 antibody; LEP-R antibody; LEPRD antibody; db antibody; Obr antibody; obl antibody; Leprb antibody; Modb1 antibody; LEPROT antibody; OB-RGRP antibody; diabetes antibody; obese-like antibody; CD295 antibody; db antibody; diabetes antibody; LEPR antibody; Lepr antibody; Leprb antibody; LEPROT antibody; MGC105189 antibody; Modb1 antibody; obese-like antibody; obl antibody; Obr antibody; OBR antibody; OB-RGRP antibody; RP23-31K16.2 antibody

Rabbit IgG

Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Rat Leptin Receptor / CD295, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is a transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one human gene that produces six different isoforms; Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression. Leptin acts via leptin receptors. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier) expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity. Mutations in Leptin Receptor/CD295 have been associated with obesity and pituitary dysfunction.