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LATS1 antibody

Cat.#: 112156

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Product Information

  • Product Name
    LATS1 antibody
  • Documents
  • Description
    LATS1 Rabbit Polyclonal antibody. Positive WB detected in mouse testis tissue, K-562 cells, mouse cerebellum tissue, SH-SY5Y cells. Positive IHC detected in human testis tissue. Observed molecular weight by Western-blot: 140kd,120kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    h warts antibody; LATS1 antibody; WARTS antibody; WARTS protein kinase antibody; wts antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of LATS1 recombinant protein (Accession Number: BC015665). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    mouse testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:112156(LATS1 antibody) at dilution of 1:500

    mouse testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:112156(LATS1 antibody) at dilution of 1:500

    Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:112156(LATS1 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:112156(LATS1 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    LATS1(Large tumor suppressor homolog 1) is also named as WARTS and belongds to the AGC Ser/Thr protein kinase family. The gene encodes a highly conserved (from fly to human) protein kinase that plays a crucial role in the prevention of tumor formation by controlling the progression of mitosis. The expression of both long(170 kDa) and short lats1 isoforms(120 kDa) in vertebrate retinal cells raises the possibility that these lats1 proteins may act as negative key regulators of the cell cycle each of them performing a unique role.(PMID:15777619). In mammalian cells, LATS1 was phosphorylated in a cell cycle-dependent manner and complexed with CDC2 in early mitosis(PMID:9988268).
  • References
    • Wang C, Zhu ZM, Liu CL, He XJ, Zhang HY, Dong JH. Knockdown of yes-associated protein inhibits proliferation and downregulates large tumor suppressor 1 expression in MHCC97H human hepatocellular carcinoma cells. Molecular medicine reports. 11(6):4101-8. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"