KIF5C antibody

KIF5C antibody

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• Material Safety Data Sheets (MSDS)

KIF5C Rabbit Polyclonal antibody. Positive WB detected in rat brain tissue. Positive IHC detected in human testis tissue, mouse brain tissue. Positive IF detected in SH-SY5Y cells. Observed molecular weight by Western-blot: 70,110 kDa

ELISA, WB, IHC, IF

Human, Rat, Mouse; other species not tested.

FLJ44735 antibody; KIAA0531 antibody; KIF5C antibody; kinesin family member 5C antibody; Kinesin heavy chain isoform 5C antibody; KINN antibody; NKHC antibody; NKHC 2 antibody; NKHC2 antibody

Rabbit IgG

This antibody was obtained by immunization of KIF5C recombinant protein (Accession Number: XM_011511157). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

KIF5C (Kinesin heavy chain isoform 5C variant) which belongs to the kinesin-like protein family is neuron specific. The kinesin-1 subfamilies (kif5a, kif5b, kif5c) are responsible for the movement of mitochondria in neurons. Kinesins have N-terminal motor domains and C-terminal cargo-binding tail domains separated by hinge regions. The hinge and C-terminal tail regions of Kif5a, Kif5b, and Kif5c bound a large detergent-resistant RNase-sensitive granule. The granule localized to dendrites and underwent bidirectional movement. Distally directed movement of the granule was enhanced by Kif5 overexpression and reduced by Kif5 functional blockage. kinesins may transport RNA in dendrites via this large granule. Two major isoforms of kif5c, with molecular predicted masses of 80 and 110 kDa, are generated by alternative splicing.