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Product Name
ITM2C antibody
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Description
ITM2C Rabbit Polyclonal antibody. Positive IHC detected in human colon tissue. Positive WB detected in Transfected HEK-293 cells. Observed molecular weight by Western-blot: 30 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
BRI3 antibody; BRICD2C antibody; Cerebral protein 14 antibody; E25 antibody; E25C antibody; integral membrane protein 2C antibody; ITM2C antibody; ITM3 antibody; PSEC0047 antibody; Transmembrane protein BRI3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ITM2C recombinant protein (Accession Number: NM_001012516). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:111954(ITM2C Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:111954(ITM2C Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:111954(ITM2C Antibody) at dilution of 1:50 (under 40x lens)
Immunofluorescent analysis of HepG2 cells using Catalog No:111954(ITM2C Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.
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