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Product Name
Rat IL7 / interleukin-7 recombinant protein
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Description
IL7, also known as interleukin 7, is a hematopoietic growth factor which belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. IL7 and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes.
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Protein name
Interleukin-7
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Protein short names
HLB368; INTERLEUKIN 7; IL7; A630026I06RIK; IL-7
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Uniprot ID
Q91Y32
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Gene Name
Il7; IL-7
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the rat IL7 (Q91Y32) (Asp26-Ile154) was expressed and purified with an initial Met.
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Protein Species
Rat
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Molecular weight
The recombinant rat IL7 consists of 130 amino acids and has a predicted molecular mass of 15 kDa. The apparent molecular mass of the recombinant protein is approximately 17 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind rat IL7R-mFc (Cat:501881) in a functional ELISA.
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Validations
Rat IL7 / interleukin 7 Protein SDS-PAGE
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