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Product Name
Human IL-1 alpha / IL-1F1 / IL1A recombinant protein
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Description
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
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Protein name
Interleukin-1 alpha
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Protein short names
IL1; IL-1 ALPHA; IL1-ALPHA; IL1F1; IL1A; IL-1A
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Uniprot ID
P01583
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Gene Name
IL1A; IL1F1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
The processed form of human IL1? (NP_000566.3) (Ser 113-Ala 271) was expressed and purified.
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Protein Species
Human
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Molecular weight
The recombinant human IL1? consists of 159 amino acids and has a predicted molecular mass of 18 kDa. As a result of glycosylation, the apparent molecular mass of rhIL1? is approximately 22 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is typically 0.2-1 ng/mL.
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Validations
Human IL-1 alpha / IL1A / IL1F1 Protein SDS-PAGE
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