-
Product Name
Mouse IL-28B/IFN-lambda-3 (His Tag) recombinant protein
- Documents
-
Description
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
-
Protein name
Interferon lambda-3
-
Protein short names
IL28B; INF-ALPHA; IFNL3; IFL-1; IL28C; IL28; INF-LAMBDA; IFN-LAMBDA-3; IL-28B
-
Uniprot ID
Q8CGK6
-
Gene Name
Ifnl3; Il28; Il28b
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the mouse Ifnl3 (NP_796370.1) (Met1-Val193) was expressed with a polyhistidine tag at the C-terminus.
-
Protein Species
Mouse
-
Molecular weight
The recombinant mouse Ifnl3 consists 185 amino acids and predicts a molecular mass of 21.1 kDa.
-
Purity
> (48.9+48.2) % as determined by SDS-PAGE.
-
Activity
Measured in antiviral assays using HepG2 cells infected with vesicular stomatitis virus.
The ED50 for this effect is typically 44.6-178.4 ng/mL. -
Validations
Mouse IL-28B / IFN-lambda-3 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"