Human IL-28B/IFN-lambda-3 (His Tag) recombinant protein

Human IL-28B/IFN-lambda-3 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda (IFN?) family of cytokines. IL-28B is a cytokine with immunomodulatory activity. It functions in Up-regulating MHC class I antigen expression. IL-28B displays potent antiviral activity and antitumor activity. This cytokine serves as ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity. Moreover, we describe for the first time how IL-28B reduces regulatory T-cell populations during DNA vaccination, whereas IL-12 increases this cellular subset. We also show that IL-28B, unlike IL-12, is able to increase the percentage of splenic CD8+ T cells in vaccinated animals, and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant.

Interferon lambda-3

INF-LAMBDA; IL28; IFN-LAMBDA-3; IL-28B; IL28B; INF-ALPHA; IFNL3; IFL-1; IL28C

Q8IZI9

IFNL3; IL28B; IL28C; ZCYTO22

Yeast

A DNA sequence encoding the human IFNL3 (NP_742151.2) (Val18-Val196) was expressed with a polyhistidine tag at the C-terminus.

Human

The recombinant human IFNL3 consists 189 amino acids and predicts a molecular mass of 21.3 kDa.

> 95 % as determined by SDS-PAGE.