-
Product Name
Integrin beta-6-Specific antibody
- Documents
-
Description
Integrin beta-6-Specific Rabbit Polyclonal antibody. Positive WB detected in A549 cells, A2780 cells. Positive IHC detected in human lung tissue. Positive IF detected in A549 cells. Observed molecular weight by Western-blot: 97 kDa
-
Tested applications
ELISA, WB, IHC, IF
-
Species reactivity
Human; other species not tested.
-
Alternative names
Integrin beta 6 antibody; integrin antibody; beta 6 antibody; ITGB6 antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_000888). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:50-1:500
-
Validations
A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:111866(ITGB6-Specific antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human lung using Catalog No:111866(ITGB6-Specific antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human lung using Catalog No:111866(ITGB6-Specific antibody) at dilution of 1:100 (under 40x lens)
Immunofluorescent analysis of (10% Formaldehyde) fixed A549 cells using Catalog No:111866(Integrin beta-6-Specific Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
-
Background
ITGB6 belongs to the integrin beta chain family. ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. The antibody is specific to ITGB6.
-
References
- Niu Z, Wang J, Muhammad S. Protein expression of eIF4E and integrin αvβ6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction. Cell & bioscience. 4:23. 2014.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"