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Integrin alpha-1 antibody

Cat.#: 111857

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Product Information

  • Product Name
    Integrin alpha-1 antibody
  • Documents
  • Description
    Integrin alpha-1 Rabbit Polyclonal antibody. Positive IHC detected in human tonsillitis tissue. Positive FC detected in HeLa cells. Positive WB detected in HepG2 cells, SMMC-7721 cells. Observed molecular weight by Western-blot: 180 kDa
  • Tested applications
    ELISA, WB, IHC, FC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    CD49a antibody; Integrin alpha 1 antibody; integrin antibody; alpha 1 antibody; ITGA1 antibody; Laminin and collagen receptor antibody; VLA 1 antibody; VLA1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Integrin alpha-1 recombinant protein (Accession Number: NM_181501). Purification method: Antigen Affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:111857(ITGA1 antibody) at dilution of 1:1000

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:111857(ITGA1 antibody) at dilution of 1:1000

    Immunohistochemistry of paraffin-embedded human tonsillitis slide using Catalog No:111857(ITGA1 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human tonsillitis slide using Catalog No:111857(ITGA1 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human tonsillitis slide using Catalog No:111857(ITGA1 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human tonsillitis slide using Catalog No:111857(ITGA1 Antibody) at dilution of 1:50 (under 10x lens)

    1X10^6 HeLa cells were stained with 0.2ug Integrin alpha-1 antibody (Catalog No:111857, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.

    1X10^6 HeLa cells were stained with 0.2ug Integrin alpha-1 antibody (Catalog No:111857, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.

  • Background
    The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-1 (ITGA1, CD49a) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor for collagen and laminin. This receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"