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Product Name
INO80 antibody
- Documents
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Description
INO80 Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells, HepG2 cells. Observed molecular weight by Western-blot: 177,150kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human; other species not tested.
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Alternative names
hINO80 antibody; INO80 antibody; INO80 homolog (S. cerevisiae) antibody; INO80A antibody; INOC1 antibody; KIAA1259 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of INO80 recombinant protein (Accession Number: NM_017553). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:111804(INO80 Antibody) at dilution of 1:600
IP Result of anti-INO80 (IP:Catalog No:111804, 4ug; Detection:Catalog No:111804 1:500) with HeLa cells lysate 2000ug.
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Background
DNA helicase INO80, also namd as INO80 or hINO80, is a 1,556 amino acid protein, which contains one helicase C-terminal domain, one helicase ATP-binding domain, and one DBINO domain. INO80 co-localizes with PCMA at replication forks during S-phase in the nucleus and belongs to the SNF2 helicase family. INO80 is a component of the chromatin remolding INO80 complex and is widely expressed in many tissues, such as brain,liver and pancreas. INO80 is involved in transcription regulation.
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References
- Kracker S, Di Virgilio M, Schwartzentruber J. An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex. The Journal of allergy and clinical immunology. 135(4):998-1007.e6. 2015.
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