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Product Name
Human INO80 Recombinant protein (GST tag)
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Description
DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. {PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20237820, PubMed:20687897, PubMed:20855601, PubMed:21303910}.
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Protein name
DNA helicase INO80
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Protein short names
INO80A; INOC1; KIAA1259
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Uniprot ID
Q9ULG1
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Gene Name
INO80; INO80A; INOC1; KIAA1259
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human INO80 (XP_054234202.1) 1217-1556 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human INO80 SDS-PAGE
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