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Product Name
IMP3 antibody
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Description
IMP3 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, MCF7 cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 22 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
BRMS2 antibody; C15orf12 antibody; DKFZp586L0118 antibody; FLJ10968 antibody; IMP3 antibody; MRPS4 antibody; U3 snoRNP protein IMP3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of IMP3 recombinant protein (Accession Number: BC020557). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:111758(IMP3 antibody) at dilution of 1:500
IP Result of anti-IMP3 (IP:Catalog No:111758, 3ug; Detection:Catalog No:111758 1:500) with HeLa cells lysate 1200ug.
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Background
IMP3 is a member of the insulin-like growth factor (IGF-II) mRNA binding protein (IMP) family that consist of IMP1, IMP2, and IMP3. IMP3 is an oncofetal protein associated with aggressive and advanced tumors and is specifically expressed in malignant tumors but not found in benign tissues [PMID:22497850]. IMP3 forms a ternary complex with IMP4 and MPP10 (MPHOSPH10) that interacts with U3 small nucleolar RNA (snoRNA), which is required for the early cleavage steps in pre-rRNA processing[PMID: 12655004].
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