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Product Name
Mouse IGSF8 (Fc Tag) recombinant protein
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Description
May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
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Protein name
Immunoglobulin superfamily member 8
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Protein short names
CD81P3; PGRL; PG REGULATORY-LIKE PROTEIN; CD316; ESTM34; AA033172; AU041109; R75384; KCT-4; EWI-2; EWI2; CD81 PARTNER 3; LIR-D1
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Uniprot ID
Q8R366
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Gene Name
Igsf8; Ewi2; Kct4; Pgrl
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse IGSF8 (NP_536344.1) extracellulkar domain (Met 1-Thr 577) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse IGSF8/Fc is a disulfide-linked homodimer. The reduced monomer comprises 793 amino acids and has a calculated molecular mass of 85.8 kDa. The apparent molecular mass of the monomer is approximately 80 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Mouse PGRL / IGSF8 Protein (Fc Tag) SDS-PAGE
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