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Product Name
IGF2BP2 antibody
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Description
IGF2BP2 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue. Positive IP detected in HEK-293 cells. Positive WB detected in human kidney tissue, COLO 320 cells, human heart tissue. Observed molecular weight by Western-blot: 65 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
IGF II mRNA binding protein 2 antibody; IGF2 mRNA binding protein 2 antibody; IGF2BP2 antibody; IMP 2 antibody; IMP2 antibody; p62 antibody; VICKZ family member 2 antibody; VICKZ2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of IGF2BP2 recombinant protein (Accession Number: NM_006548). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human kidney tissue were subjected to SDS PAGE followed by western blot with Catalog No:111680(IGF2BP2 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:111680(IGF2BP2 antibody) at dilution of 1:50 (under 10x lens)
IP Result of anti-IGF2BP2 (IP:Catalog No:111680, 3ug; Detection:Catalog No:111680 1:500) with HEK-293 cells lysate 1000ug.
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Background
Insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2), ia a member of a family of mRNA binding protein, which can bind to several mammalian cells' mRNAs. Thus it may involve in the regulation of translation of mRNA. IGF2BP2's polymorphisms is risk factor for developing type 2 diabetes. This antibody raise against part of N-terminus of human IGF2BP2.
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References
- Li W, Liu D, Chang W. Role of IGF2BP3 in trophoblast cell invasion and migration. Cell death & disease. 5:e1025. 2014.
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