IER3 Polyclonal Antibody

Cat.#: 165963

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Product Information

  • Product Name
    IER3 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to IER3
  • Tested applications
    WB, IHC
  • Species reactivity
    Human, Mouse
  • Alternative names
    IER3 antibody; DIF-2 antibody; DIF2 antibody; GLY96 antibody; IEX-1 antibody; IEX-1L antibody; IEX1 antibody; PRG1 antibody; immediate early response 3 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human IER3 (NP_003888.2).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IHC 1:50 - 1:100
  • Validations

    Western blot - IER3 Polyclonal Antibody

    Western blot - IER3 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using IER3 Antibody at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit ._Exposure time: 90s.

    Immunohistochemistry - IER3 Polyclonal Antibody

    Immunohistochemistry - IER3 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded mouse stomach using IER3 antibody at dilution of 1:100 (40x lens).

    Immunohistochemistry - IER3 Polyclonal Antibody

    Immunohistochemistry - IER3 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded human gastric cancer using IER3 antibody at dilution of 1:100 (40x lens).

  • Background
    May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"